Sustained-release drug delivery systems

Williams, Rachel ORCID: 0000-0002-1954-0256, Cauldbeck, Helen ORCID: 0000-0002-2853-8457 and Kearns, Victoria ORCID: 0000-0003-1426-6048 (2025) Sustained-release drug delivery systems Eye, 39 (4). pp. 658-666. ISSN 0950-222X, 1476-5454

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Abstract

AbstractThe design and development of a sustained-release drug delivery system targeting the administration of active pharmaceutical ingredients (APIs) to the eye could overcome the limitations of topically administered eye drops. Understanding how to modify or design new materials with specific functional properties that promote the attachment and release of specific drugs over longer time periods, alongside understanding clinical needs, can lead to new strategic opportunities to improve treatment options. In this paper we discuss two approaches to the design or modification of materials to produce a sustained therapeutic effect. Firstly, we discuss how the synthesis of a peptide hydrogel from a naturally-derived antimicrobial material led to the design of a bandage contact lens which may be able to be used prophylactically to reduce post-surgery infection. Secondly, we discuss how silicone oil tamponade agents used to treat retinal detachments can have adjunctive behaviour to enhance the solubility of the anti-proliferative drug retinoic acid and produce a sustained release over several weeks. These studies are the result of close partnerships between clinical ophthalmologists, materials scientists, and chemists, and illustrate how these partnerships can lead to comprehensive understandings that have the potential to change patient outcomes.

Item Type:	Article
Uncontrolled Keywords:	Humans, Retinal Detachment, Silicone Oils, Delayed-Action Preparations, Ophthalmic Solutions, Drug Delivery Systems
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	20 May 2024 08:29
Last Modified:	22 May 2026 21:34
DOI:	10.1038/s41433-024-03134-w
Open Access URL:	https://doi.org/10.1038/s41433-024-03134-w
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3181761
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