Biomechanical considerations for optimising subretinal injections.

L'Abbate, Dario, Prescott, Kia, Geraghty, Brendan ORCID: 0000-0003-0561-6667, Kearns, Victoria R ORCID: 0000-0003-1426-6048 and Steel, David HW (2024) Biomechanical considerations for optimising subretinal injections. Survey of ophthalmology, 69 (5). S0039-6257(24)00053-5-S0039-6257(24)00053-5. ISSN 0039-6257, 1879-3304

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Abstract

Subretinal injection is the preferred delivery technique for various novel ocular therapies and is widely used because of its precision and efficient delivery of gene and cell therapies; however, choosing an injection point and defining delivery parameters to target a specified retinal location and area is an inexact science. We provide an overview of the key factors that play important roles during subretinal injections to refine the technique, enhance patient outcomes, and minimise risks. We describe the role of anatomical and physical variables that affect subretinal bleb propagation and shape and their impact on retinal integrity. We highlight the risks associated with subretinal injections and consider strategies to mitigate reflux and retinal trauma. Finally, we explore the emerging field of robotic assistance in improving intraocular manouvrability and precision to facilitate the injection procedure.

Item Type:	Article
Uncontrolled Keywords:	Retina, Vitrectomy, Subretinal injection, Subretinal bleb, Retinal trauma, Gene therapy, Robotic assistance, Reflux
Depositing User:	Symplectic Admin
Date Deposited:	05 Aug 2024 15:44
Last Modified:	22 May 2026 22:10
DOI:	10.1016/j.survophthal.2024.05.004
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3183334
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