Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID.


Elneima, Omer, Hurst, John R, Echevarria, Carlos, Quint, Jennifer K, Walker, Samantha, Siddiqui, Salman, Novotny, Petr, Pfeffer, Paul E, Brown, Jeremy S, Shankar-Hari, Manu et al (show 25 more authors) (2024) Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID. ERJ open research, 10 (4). pp. 982-2023. ISSN 2312-0541, 2312-0541

[thumbnail of Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK a multicentre, lo.pdf] PDF
Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK a multicentre, lo.pdf - Open Access published version
Download (1MB) | Preview

Abstract

<h4>Background</h4>The long-term outcomes of COVID-19 hospitalisation in individuals with pre-existing airway diseases are unknown.<h4>Methods</h4>Adult participants hospitalised for confirmed or clinically suspected COVID-19 and discharged between 5 March 2020 and 31 March 2021 were recruited to the Post-hospitalisation COVID-19 (PHOSP-COVID) study. Participants attended research visits at 5 months and 1 year post discharge. Clinical characteristics, perceived recovery, burden of symptoms and health-related quality of life (HRQoL) of individuals with pre-existing airway disease (<i>i.e.</i>, asthma, COPD or bronchiectasis) were compared to the non-airways group.<h4>Results</h4>A total of 615 out of 2697 (22.8%) participants had a history of pre-existing airway diseases (72.0% diagnosed with asthma, 22.9% COPD and 5.1% bronchiectasis). At 1 year, the airways group participants were less likely to feel fully recovered (20.4% <i>versus</i> 33.2%, p<0.001), had higher burden of anxiety (29.1% <i>versus</i> 22.0%, p=0.002), depression (31.2% <i>versus</i> 24.7%, p=0.006), higher percentage of impaired mobility using short physical performance battery ≤10 (57.4% <i>versus</i> 45.2%, p<0.001) and 27% had a new disability (assessed by the Washington Group Short Set on Functioning) <i>versus</i> 16.6%, p=0.014. HRQoL assessed using EQ-5D-5L Utility Index was lower in the airways group (mean±SD 0.64±0.27 <i>versus</i> 0.73±0.25, p<0.001). Burden of breathlessness, fatigue and cough measured using a study-specific tool was higher in the airways group.<h4>Conclusion</h4>Individuals with pre-existing airway diseases hospitalised due to COVID-19 were less likely to feel fully recovered, had lower physiological performance measurements, more burden of symptoms and reduced HRQoL up to 1 year post-hospital discharge.

Item Type: Article
Uncontrolled Keywords: 32 Biomedical and Clinical Sciences, 3201 Cardiovascular Medicine and Haematology, 3211 Oncology and Carcinogenesis, Infectious Diseases, Coronaviruses, Clinical Research, Emerging Infectious Diseases, Lung, Asthma, Respiratory, 3 Good Health and Well Being
Depositing User: Symplectic Admin
Date Deposited: 27 Aug 2024 07:38
Last Modified: 06 Feb 2026 18:09
DOI: 10.1183/23120541.00982-2023
Related Websites:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3184068
Disclaimer: The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate.
Altmetric
CORE (COnnecting REpositories)