Analysis of commercially available snake antivenoms reveals high contents of endotoxins in some products.

Solano, Gabriela, Ainsworth, Stuart ORCID: 0000-0002-0199-6482, Sánchez, Adriana, Villalta, Mauren, Sánchez, Paola, Durán, Gina, Gutiérrez, José María and León, Guillermo (2024) Analysis of commercially available snake antivenoms reveals high contents of endotoxins in some products. Toxicon: X, 21. 100187-. ISSN 2590-1710, 2590-1710

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Abstract

As injectable therapeutics, snake antivenoms must meet specifications for endotoxin content. The <i>Limulus</i> amebocyte lysate (LAL) test was used to evaluate the endotoxin content in several commercially available antivenoms released for clinical use. It was found that some products have endotoxin concentrations higher than the accepted limit for these contaminants. These results emphasize the need to include endotoxin determination as part of the routine evaluation of antivenoms by manufacturers and regulatory agencies.

Item Type:	Article
Uncontrolled Keywords:	Endotoxin, Limulus amebocyte lysate test, Pyrogen, Snake antivenom
Depositing User:	Symplectic Admin
Date Deposited:	03 Sep 2024 08:34
Last Modified:	08 Dec 2024 02:06
DOI:	10.1016/j.toxcx.2024.100187
Open Access URL:	https://www.sciencedirect.com/science/article/pii/...
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3184211