Rosenberger, Albert, Bickeböller, Heike, Christiani, David C, Liu, Geoffrey, Schabath, Matthew B, Duarte, Luisa F, Le Marchand, Loic, Haiman, Christopher, Landi, Teresa, Consonni, Dario et al (show 8 more authors)
(2024)
On the informative value of community-based indoor radon values in relation to lung cancer.
Cancer medicine, 13 (16).
e70126-e70126.
ISSN 2045-7634, 2045-7634
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Abstract
<h4>Background</h4>Radon is a radioactive gas and a major risk factor for lung cancer (LC).<h4>Methods</h4>We investigated the dose-response relationship between radon and LC risk in the International Lung Cancer Consortium with 8927 cases and 5562 controls from Europe, North America, and Israel, conducted between 1992 and 2016. Spatial indoor radon exposure in the residential area (sIR) obtained from national surveys was linked to the participants' residential geolocation. Parametric linear and spline functions were fitted within a logistic regression framework.<h4>Results</h4>We observed a non-linear spatial-dose response relationship for sIR < 200 Bq/m<sup>3</sup>. The lowest risk was observed for areas of mean exposure of 58 Bq/m<sup>3</sup> (95% CI: 56.1-59.2 Bq/m<sup>3</sup>). The relative risk of lung cancer increased to the same degree in areas averaging 25 Bq/m<sup>3</sup> (OR = 1.31, 95% CI: 1.01-1.59) as in areas with a mean of 100 Bq/m<sup>3</sup> (OR = 1.34, 95% CI: 1.20-1.45). The strongest association was observed for small cell lung cancer and the weakest for squamous cell carcinoma. A stronger association was also observed in men, but only at higher exposure levels. The non-linear association is primarily observed among the younger population (age < 69 years), but not in the older population, which can potentially represent different biological radiation responses.<h4>Conclusions</h4>The sIR is useful as proxy of individual radon exposure in epidemiological studies on lung cancer. The usual assumption of a linear, no-threshold dose-response relationship, as can be made for individual radon exposures, may not be optimal for sIR values of less than 200 Bq/m<sup>3</sup>.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | histological subtypes, lung cancer, radiation, smoking |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 14 Oct 2024 09:40 |
| Last Modified: | 28 Feb 2026 01:06 |
| DOI: | 10.1002/cam4.70126 |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3185065 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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