Imaging timing after surgery for glioblastoma: an evaluation of practice in Great Britain and Ireland (INTERVAL-GB)- a multi-centre, cohort study.


INTERVAL-GB Collaborative, Neurology and Neurosurgery Interest Group (NANSIG) and British Neurosurgical Trainee Research Collaborative (BNTRC) (2024) Imaging timing after surgery for glioblastoma: an evaluation of practice in Great Britain and Ireland (INTERVAL-GB)- a multi-centre, cohort study. Journal of neuro-oncology, 169 (3). pp. 517-529. ISSN 0167-594X, 1573-7373

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Abstract

<h4>Purpose</h4>Post-operative MRI is used to assess extent of resection, monitor treatment response and detect progression in high-grade glioma. However, compliance with accepted guidelines for follow-up MRI, and impact on management/outcomes is unclear.<h4>Methods</h4>Multi-center, retrospective observational cohort study of patients with confirmed WHO grade 4 glioma (August 2018-February 2019) receiving oncological treatment.<h4>Primary objective</h4>investigate follow-up MRI surveillance practice and compliance with recommendations from NICE (Post-operative scan < 72h, MRI every 3-6 months) and EANO (Post-operative scan < 48h, MRI every 3 months).<h4>Results</h4>There were 754 patients from 26 neuro-oncology centers with a median age of 63 years (IQR 54-70), yielding 10,100 (median, 12.5/person, IQR 5.2-19.4) person-months of follow-up. Of patients receiving debulking surgery, most patients had post-operative MRI within 72 h of surgery (78.0%, N = 407/522), and within 48 h of surgery (64.2%, N = 335/522). The median number of subsequent follow-up MRI scans was 1 (IQR 0-4). Compliance with NICE and EANO recommendations for follow-up MRI was 52.8% (N = 398/754) and 24.9% (N = 188/754), respectively. On multivariable Cox regression analysis, increased time spent in recommended follow-up according to NICE guidelines was associated with longer OS (HR 0.56, 95% CI 0.46-0.66, P < 0.001), but not PFS (HR 0.93, 95% CI 0.79-1.10, P = 0.349). Increased time spent in recommended follow-up according to EANO guidelines was associated with longer OS (HR 0.54, 95% CI 0.45-0.63, P < 0.001) but not PFS (HR 0.99, 95% CI 0.84-1.16, P = 0.874).<h4>Conclusion</h4>Regular surveillance follow-up for glioblastoma is associated with longer OS. Prospective trials are needed to determine whether regular or symptom-directed MRI influences outcomes.

Item Type: Article
Uncontrolled Keywords: INTERVAL-GB Collaborative, Neurology and Neurosurgery Interest Group (NANSIG), British Neurosurgical Trainee Research Collaborative (BNTRC), Humans, Glioblastoma, Brain Neoplasms, Magnetic Resonance Imaging, Retrospective Studies, Cohort Studies, Follow-Up Studies, Time Factors, Aged, Middle Aged, Guideline Adherence, Ireland, Female, Male, United Kingdom
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 04 Nov 2024 08:58
Last Modified: 09 Dec 2024 11:16
DOI: 10.1007/s11060-024-04705-3
Related Websites:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3187019
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