Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant <i>Candida auris</i>.


Kappel, Dana, Gifford, Hugh, Brackin, Amelie, Abdolrasouli, Alireza, Eyre, David W ORCID: 0000-0001-5095-6367, Jeffery, Katie, Schlenz, Silke, Aanensen, David M, Brown, Colin S, Borman, Andrew ORCID: 0000-0003-0585-5721 et al (show 5 more authors) (2024) Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant <i>Candida auris</i>. npj antimicrobials and resistance, 2 (1). 26-. ISSN 2731-8745, 2731-8745

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Abstract

<i>Candida auris</i> is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant <i>C. auris</i> within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of <i>C. auris</i> introductions and infer subsequent patterns of inter- and intra-hospital transmission of azole drug-resistant isolates. We identify at least one introduction from Clade I and two from Clade III into the UK, and observe temporal and geographical evidence for multiple transmission events of antifungal drug resistant isolates between hospitals and identified local within-hospital patient-to-patient transmission events. Our study confirms outbreaks of drug-resistant <i>C. auris</i> are linked and that transmission amongst patients occurs, explaining local hospital outbreaks, and demonstrating a need for improved epidemiological surveillance of <i>C. auris</i> to protect patients and healthcare services.

Item Type: Article
Uncontrolled Keywords: Eukaryote, Evolutionary ecology, Evolutionary genetics, Fungal evolution, Fungal genomics
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 07 Nov 2024 16:07
Last Modified: 14 Jun 2025 04:23
DOI: 10.1038/s44259-024-00043-6
Related Websites:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3187156
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