Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction.

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Wood, Greta K ORCID: 0000-0001-6098-2331, Sargent, Brendan F, Ahmad, Zain-Ul-Abideen, Tharmaratnam, Kukatharmini ORCID: 0000-0002-8255-9822, Dunai, Cordelia ORCID: 0000-0001-5799-2387, Egbe, Franklyn N, Martin, Naomi H, Facer, Bethany, Pendered, Sophie L, Rogers, Henry C et al (show 46 more authors) , Hübel, Christopher, van Wamelen, Daniel J, Bethlehem, Richard AI, Giunchiglia, Valentina, Hellyer, Peter J, Trender, William, Kalsi, Gursharan, Needham, Edward, Easton, Ava, Jackson, Thomas A, Cunningham, Colm, Upthegrove, Rachel, Pollak, Thomas A, Hotopf, Matthew, Solomon, Tom ORCID: 0000-0001-7266-6547, Pett, Sarah L, Shaw, Pamela J, Wood, Nicholas, Harrison, Neil A, Miller, Karla L, Jezzard, Peter, Williams, Guy, Duff, Eugene P, Williams, Steven, Zelaya, Fernando, Smith, Stephen M, Keller, Simon ORCID: 0000-0001-5247-9795, Broome, Matthew, Kingston, Nathalie, Husain, Masud, Vincent, Angela, Bradley, John, Chinnery, Patrick, Menon, David K, Aggleton, John P, Nicholson, Timothy R, Taylor, John-Paul, David, Anthony S, Carson, Alan, Bullmore, Ed, Breen, Gerome, Hampshire, Adam, COVID-CNS Consortium, Michael, Benedict D ORCID: 0000-0002-8693-8926, Paddick, Stella-Maria and Leek, E Charles ORCID: 0000-0001-9258-7504 (2024) Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction. Nature medicine, 31 (1). pp. 245-247. ISSN 1078-8956, 1546-170X

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Abstract

The spectrum, pathophysiology, and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the one-year cognitive, serum biomarker, and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who had required hospitalisation, compared to 2,927 normative matched controls. Cognitive deficits were global and associated with elevated brain injury markers, and reduced anterior cingulate cortex volume one year after COVID-19. The severity of the initial infective insult, post-acute psychiatric symptoms, and a history of encephalopathy were associated with greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies.

Item Type:	Article
Uncontrolled Keywords:	COVID-CNS Consortium
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences Faculty of Health & Life Sciences > Inst. Population Health Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	15 Nov 2024 13:44
Last Modified:	23 May 2026 09:19
DOI:	10.1038/s41591-024-03309-8
Open Access URL:	https://doi.org/10.1038/s41591-024-03309-8
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3188030
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