Betancourt, Andrea J 
ORCID: 0000-0001-9351-1413, Wei, Kevin H-C, Huang, Yuheng and Lee, Yuh Chwen G
(2024)
Causes and Consequences of Varying Transposable Element Activity: An Evolutionary Perspective.
Annual Review of Genomics and Human Genetics, 25 (1).
pp. 1-25.
ISSN 1527-8204, 1545-293X
Abstract
Transposable elements (TEs) are genomic parasites found in nearly all eukaryotes, including humans. This evolutionary success of TEs is due to their replicative activity, involving insertion into new genomic locations. TE activity varies at multiple levels, from between taxa to within individuals. The rapidly accumulating evidence of the influence of TE activity on human health, as well as the rapid growth of new tools to study it, motivated an evaluation of what we know about TE activity thus far. Here, we discuss why TE activity varies, and the consequences of this variation, from an evolutionary perspective. By studying TE activity in nonhuman organisms in the context of evolutionary theories, we can shed light on the factors that affect TE activity. While the consequences of TE activity are usually deleterious, some have lasting evolutionary impacts by conferring benefits on the host or affecting other evolutionary processes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Animals, Humans, DNA Transposable Elements, Evolution, Molecular |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Dec 2024 13:32 |
| Last Modified: | 20 Dec 2024 13:32 |
| DOI: | 10.1146/annurev-genom-120822-105708 |
| Open Access URL: | https://doi.org/10.1146/annurev-genom-120822-10570... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3189376 |
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