Federated privacy-protected meta- and mega-omics data analysis in multi-center studies with a fully open-source analytic platform

Escriba-Montagut, Xavier, Marcon, Yannick, Anguita-Ruiz, Augusto, Avraam, Demetris, Urquiza, Jose, Morgan, Andrei S, Wilson, Rebecca C ORCID: 0000-0003-2294-593X, Burton, Paul and Gonzalez, Juan R (2024) Federated privacy-protected meta- and mega-omics data analysis in multi-center studies with a fully open-source analytic platform PLOS COMPUTATIONAL BIOLOGY, 20 (12). e1012626-. ISSN 1553-734X, 1553-7358

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Abstract

The importance of maintaining data privacy and complying with regulatory requirements is highlighted especially when sharing omic data between different research centers. This challenge is even more pronounced in the scenario where a multi-center effort for collaborative omics studies is necessary. OmicSHIELD is introduced as an open-source tool aimed at overcoming these challenges by enabling privacy-protected federated analysis of sensitive omic data. In order to ensure this, multiple security mechanisms have been included in the software. This innovative tool is capable of managing a wide range of omic data analyses specifically tailored to biomedical research. These include genome and epigenome wide association studies and differential gene expression analyses. OmicSHIELD is designed to support both meta- and mega-analysis, so that it offers a wide range of capabilities for different analysis designs. We present a series of use cases illustrating some examples of how the software addresses real-world analyses of omic data

Item Type:	Article
Uncontrolled Keywords:	Humans, Computational Biology, Genomics, Privacy, Computer Security, Software, Multicenter Studies as Topic, Genome-Wide Association Study, Data Analysis
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Population Health
Depositing User:	Symplectic Admin
Date Deposited:	31 Jan 2025 16:03
Last Modified:	16 Jun 2026 20:12
DOI:	10.1371/journal.pcbi.1012626
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3190054
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