Deletion of 17p in cancers: Guilt by (p53) association


van Kampen, Francisca, Clark, Abigail, Soul, Jamie ORCID: 0000-0003-2255-6459, Kanhere, Aditi ORCID: 0000-0001-5464-9006, Glenn, Mark A ORCID: 0009-0005-2490-2740, Pettitt, Andrew R ORCID: 0000-0002-0907-8950, Kalakonda, Nagesh ORCID: 0000-0002-5300-1360 and Slupsky, Joseph R ORCID: 0000-0002-7410-9004 (2025) Deletion of 17p in cancers: Guilt by (p53) association. Oncogene, 44 (10). pp. 637-651. ISSN 0950-9232, 1476-5594

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Abstract

<jats:title>Abstract</jats:title> <jats:p>Monoallelic deletion of the short arm of chromosome 17 (del17p) is a recurrent abnormality in cancers with poor outcomes. Best studied in relation to haematological malignancies, associated functional outcomes are attributed mainly to loss and/or dysfunction of <jats:italic>TP53</jats:italic>, which is located at 17p13.1, but the wider impact of deletion of other genes located on 17p is poorly understood. 17p is one of the most gene-dense regions of the genome and includes tumour suppressor genes additional to <jats:italic>TP53</jats:italic>, genes essential for cell survival and proliferation, as well as small and long non-coding RNAs. In this review we utilise a data-driven approach to demarcate the extent of 17p deletion in multiple cancers and identify a common loss-of-function gene signature. We discuss how the resultant loss of heterozygosity (LOH) and haploinsufficiency may influence cell behaviour but also identify vulnerabilities that can potentially be exploited therapeutically. Finally, we highlight how emerging animal and isogenic cell line models of del17p can provide critical biological insights for cancer cell behaviour.</jats:p>

Item Type: Article
Uncontrolled Keywords: Chromosomes, Human, Pair 17, Animals, Humans, Neoplasms, Chromosome Deletion, Loss of Heterozygosity, Tumor Suppressor Protein p53, Haploinsufficiency, Smith-Magenis Syndrome
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 19 Feb 2025 09:16
Last Modified: 14 May 2025 12:08
DOI: 10.1038/s41388-025-03300-8
Related Websites:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3190385
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