Danciu, CG 
ORCID: 0000-0003-1394-920X, Gonçalves, R ORCID: 0000-0001-5420-9801, Caldero, CJ, Posporis, C, Espinosa, J, de Decker, S ORCID: 0000-0002-2505-2152, Gredal, H and Wyatt, SE
(2025)
Comorbidities, long-term outcome and poststroke epilepsy associated with ischemic stroke – A multicenter observational study of 125 dogs
Journal of Veterinary Internal Medicine, 39 (1).
e17291-.
ISSN 0891-6640, 1939-1676
Abstract
Background: Little is known regarding the comorbidities and prognostic factors associated with the long-term outcome of ischemic stroke in dogs. Although poststroke epilepsy is a well-recognized syndrome in people, it is unclear if this phenomenon also occurs in dogs. Hypothesis/objective: Document comorbidities, long-term outcome (survival and stroke recurrence), and occurrence of epileptic seizures associated with ischemic stroke. Animals: One hundred and twenty-five client-owned dogs. Methods: Multicenter observational study including dogs diagnosed with ischemic stroke between 2000 and 2021. Associations between comorbidities, stroke location and extent, poststroke epileptic seizures, and long-term outcome were investigated. Referring veterinarians and owners were contacted to obtain follow-up information. Results: Fifty-two dogs (41.6%) had a comorbidity. The most common comorbidities were hypertension (20%) and proteinuria (8%). Eight dogs (6.4%) that did not survive to discharge had a territorial ischemic stroke. Overall median survival time for dogs with a comorbidity was 482 days (range, 1-3013) and 907 days (range, 1-3027) in dogs without comorbidities (Kaplan-Meier survival analysis P =.602). Twenty-four dogs (19.2%) had a suspected stroke recurrence and a total of 8/109 dogs (7.3%) developed poststroke epilepsy. No association was found between suspected stroke recurrence or development of poststroke epilepsy and survival (P =.812, P =.487). Conclusions and Clinical Importance: Despite no significant difference in survival of dogs diagnosed with ischemic stroke, with or without comorbidities, investigations for underlying causes are recommended to provide appropriate treatment. Poststroke epilepsy is uncommon.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Animals, Dogs, Epilepsy, Proteinuria, Hypertension, Dog Diseases, Recurrence, Comorbidity, Female, Male, Ischemic Stroke |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 28 Feb 2025 16:15 |
| Last Modified: | 09 Feb 2026 14:38 |
| DOI: | 10.1111/jvim.17291 |
| Open Access URL: | https://doi.org/10.1111/jvim.17291 |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3190589 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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