Footprints in the Sno: investigating the cellular and molecular mechanisms of SNORD116.

Holmes, Terri L, Chabronova, Alzbeta ORCID: 0000-0002-9733-444X, Denning, Chris, James, Victoria, Peffers, Mandy J ORCID: 0000-0001-6979-0440 and Smith, James GW (2025) Footprints in the Sno: investigating the cellular and molecular mechanisms of SNORD116. Open biology, 15 (3). p. 240371. ISSN 2046-2441, 2046-2441

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Abstract

The small nucleolar RNA (snoRNA) SNORD116 is a small non-coding RNA of interest across multiple biomedical fields of research. Much of the investigation into SNORD116 has been undertaken in the context of the congenital disease Prader-Willi syndrome, wherein SNORD116 expression is lost. However, emerging evidence indicates wider roles in various disease and tissue contexts such as cellular growth, metabolism and signalling. Nevertheless, a conclusive mechanism of action for SNORD116 remains to be established. Here, we review the key findings from these investigations, with the aim of identifying common elements from which to elucidate potential targets and mechanisms of SNORD116. A key recurring element identified is disruption to the insulin/IGF-1 and PI3K/mTOR signalling pathways, contributing to many of the phenotypes associated with SNORD116 modulation explored in this review.

Item Type:	Article
Uncontrolled Keywords:	SNORD116, snoRNA, metabolism, cell signalling, Prader-Willi syndrome
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	25 Mar 2025 10:19
Last Modified:	28 Feb 2026 17:27
DOI:	10.1098/rsob.240371
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3190974
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