Park, Yeon Joon, German, Alexander J 
ORCID: 0000-0002-3017-7988, Brewer, David and O'Connell, Erin ORCID: 0000-0003-0400-9291
(2025)
A Retrospective Evaluation of Serum Symmetric Dimethylarginine Concentration in Dogs With Protein-Losing Enteropathy.
Journal of veterinary internal medicine, 39 (2).
e70068-e70068.
ISSN 0891-6640, 1939-1676
Abstract
Serum symmetric dimethylarginine (SDMA) is abnormally increased in people with inflammatory bowel disease (IBD). Changes in dogs with gastrointestinal disease, such as protein-losing enteropathy (PLE), have not been assessed. Evaluate SDMA concentration in non-azotemic dogs with PLE. A total of 127 client-owned dogs, 17 with PLE, 34 controls matched for age, breed, sex, and neuter status, and 76 additional controls for multiple linear regression modeling. Retrospective case-control study. The clinical records of a United Kingdom referral hospital were reviewed. Dogs with azotemia or prior glucocorticoid or immunosuppressive treatment were excluded. Dogs diagnosed with PLE that had serum symmetric dimethylarginine (SDMA) concentrations measured were compared with the matched controls. Signalment, clinical presentation, clinicopathological abnormalities, treatment, and SDMA concentration pre- (PLE-T0) and post- (PLE-T1) treatment were recorded. At baseline, SDMA concentration was higher in PLE (T0, 15.2 ± 2.02 μg/dL) than in control (11.0 ± 3.13 μg/dL) dogs (p < 0.001; Hedge's G, 1.48), but decreased with treatment (PLE-T1: 10.3 ± 2.78 μg/dL; T0 vs. T1: p = 0.01, Hedge's G, 1.31). Serum creatinine concentration was similar in PLE (T0, 0.81 ± 0.24 μg/dL) and control (0.85 ± 0.26 μg/dL) dogs at baseline (p = 0.57; Hedge's G, 0.18). Serum albumin concentration was lower in PLE (1.60 ± 0.51 g/dL) than in control (2.96 ± 0.49 g/dL) dogs (p < 0.001; Hedge's G, 2.68) before treatment, but increased with treatment (PLE-T1: 2.29 ± 0.65 g/dL; T0 vs. T1: p = 0.003; Hedge's G, 1.14), although it remained lower than the concentration in controls (p = 0.002; Hedge's G, 1.23). No other clinicopathological differences were evident. Serum SDMA concentration is increased in dogs with PLE; the clinical relevance of this finding requires further investigation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | chronic enteropathy, gastrointestinal disease, GFR, renal biomarker |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 28 Mar 2025 10:25 |
| Last Modified: | 08 Apr 2026 19:32 |
| DOI: | 10.1111/jvim.70068 |
| Open Access URL: | https://doi.org/10.1111/jvim.70068 |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3191088 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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