Wan, Yu 
ORCID: 0000-0002-8354-7647, Pike, Rachel, Harley, Alessandra, Mumin, Zaynab, Potterill, Isabelle, Meunier, Danièle, Ganner, Mark, Getino, Maria, Coelho, Juliana, Jauneikaite, Elita ORCID: 0000-0002-7075-6896 et al (show 6 more authors)
(2025)
Complete genome assemblies and antibiograms of 22 Staphylococcus capitis isolates.
BMC genomic data, 26 (1).
12-.
ISSN 2730-6844, 2730-6844
Abstract
<h4>Objective</h4>Staphylococcus capitis is part of the human microbiome and an opportunistic pathogen known to cause catheter-associated bacteraemia, prosthetic joint infections, skin and wound infections, among others. Detection of S. capitis in normally sterile body sites saw an increase over the last decade in England, where a multidrug-resistant clone, NRCS-A, was widely identified in blood samples from infants in neonatal intensive care units. To address a lack of complete genomes and antibiograms of S. capitis in public databases, we performed long- and short-read whole-genome sequencing, hybrid genome assembly, and antimicrobial susceptibility testing of 22 diverse isolates.<h4>Data description</h4>We present complete genome assemblies of two S. capitis type strains (subspecies capitis: DSM 20326; subspecies urealyticus: DSM 6717) and 20 clinical isolates (NRCS-A: 10) from England. Each genome is accompanied by minimum inhibitory concentrations of 13 antimicrobials including vancomycin, teicoplanin, daptomycin, linezolid, and clindamycin. These 22 genomes were 2.4-2.7 Mbp in length and had a GC content of 33%. Plasmids were identified in 20 isolates. Resistance to teicoplanin, daptomycin, gentamicin, fusidic acid, rifampicin, ciprofloxacin, clindamycin, and erythromycin was seen in 1-10 isolates. Our data are a resource for future studies on genomics, evolution, and antimicrobial resistance of S. capitis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Staphylococcal Infections, Anti-Bacterial Agents, Microbial Sensitivity Tests, Drug Resistance, Multiple, Bacterial, Genome, Bacterial, Whole Genome Sequencing, Staphylococcus capitis |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 04 Apr 2025 09:21 |
| Last Modified: | 04 Apr 2025 09:21 |
| DOI: | 10.1186/s12863-025-01303-8 |
| Open Access URL: | https://doi.org/10.1186/s12863-025-01303-8 |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3191206 |
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