Strutt, Jemima, Ashpole, Ian, Orlowska, Anna, Tilston, Valerie, Barbon, Alberto R, Rocchigiani, Guido 
ORCID: 0000-0002-3742-7636, Chantrey, Julian ORCID: 0000-0002-4801-7034 and Van de Weyer, Yannick
(2025)
Multicentric B-cell lymphoma, phaeochromocytoma and amyloid-rich thyroid carcinoma in a common warthog (Phacochoerus africanus): a case of multiple endocrine neoplasia type 2?
Journal of Comparative Pathology, 219.
pp. 82-87.
ISSN 0021-9975, 1532-3129
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Abstract
Neoplastic diseases are poorly documented in Suidae species. This report describes a 15-year-old female common warthog (Phacochoerus africanus) with multicentric lymphoma, phaeochromocytoma and C-cell carcinoma. The animal had multiple episodes of weakness and epistaxis in the months before death, until it was euthanized for acute lethargy and recumbency. Post-mortem examination revealed haemoabdomen originating from enlarged lymph nodes at the mesenteric root. The warthog had generalized lymphadenopathy, consistent with B-cell lymphoma based on CD20 immunohistochemistry. The adrenal glands were bilaterally enlarged, one by an ovoid mass arising from the medulla that effaced the cortex, consistent with a well-differentiated phaeochromocytoma, based on histomorphology and chromogranin A immunopositivity. This animal also had a unilateral, encapsulated thyroid nodule characterized by abundant interstitial calcitonin-positive amyloid and irregular tubular structures, similar to human medullary thyroid carcinoma. There was moderate metastatic calcification of the lungs and upper respiratory mucosa, presumably part of a paraneoplastic syndrome. The combination of phaeochromocytoma and an amyloid-rich thyroid carcinoma in this animal is suggestive of multiple endocrine neoplasia type 2 syndrome which, although well described in humans, is rarely reported in animals. Further investigations of genetic aspects are recommended.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Animals, Rodentia, Lymphoma, B-Cell, Pheochromocytoma, Adrenal Gland Neoplasms, Multiple Endocrine Neoplasia Type 2a, Thyroid Neoplasms, Female |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 14 May 2025 10:45 |
| Last Modified: | 21 Jun 2025 11:41 |
| DOI: | 10.1016/j.jcpa.2025.04.008 |
| Open Access URL: | https://www.sciencedirect.com/science/article/pii/... |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3192743 |
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