Development and validation of an eating behavior patient-reported outcome measure in people living with obesity or overweight.


Bushnell, Donald M ORCID: 0000-0001-9226-1678, Fung, Shirley, Brod, Meryl ORCID: 0000-0002-0663-5838, Roberts, Carl A ORCID: 0000-0003-4275-601X, Le Roux, Carel W ORCID: 0000-0001-5521-5445, Steen, Oren ORCID: 0000-0001-8604-6891, Lucas, Kathryn J, Hennige, Anita M and Uster, Anastasia ORCID: 0009-0004-2135-2061 (2025) Development and validation of an eating behavior patient-reported outcome measure in people living with obesity or overweight. Obesity (Silver Spring, Md.), 33 (7). pp. 1249-1262. ISSN 1930-7381, 1930-739X

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Abstract

<h4>Objective</h4>The objective of this study was to develop a measure of eating behaviors in adults living with obesity or overweight.<h4>Methods</h4>Based on concept-elicitation (n = 53) and cognitive-debriefing (n = 15) studies, a draft eating behavior patient-reported outcome (EB PRO) measure was developed. Its psychometric properties were established using data from a 46-week clinical trial of an investigational antiobesity medication (n = 387).<h4>Results</h4>The final EB PRO comprised 12 items across two domains (i.e., "Desire to Eat" and "Capacity to Resist"; 6 items each) and a Total Eating Behavior score (0-48; higher scores worse). The EB PRO demonstrated good test-retest reliability (intraclass correlation coefficients > 0.7). Confirmatory factor analysis showed a comparative fit index of 0.98 with good internal consistency (Cronbach α > 0.7). The EB PRO generally exhibited moderate-to-large correlations with the Patient Global Impression of Severity questionnaire and Three-Factor Eating Questionnaire and weaker correlation with the 36-Item Short-Form Health Survey version 2 Physical Functioning scale. All EB PRO scores improved from baseline to week 46 (p < 0.0001), demonstrating sensitivity to change with therapy. Clinically meaningful thresholds were defined as eight- and four-point changes in Total Eating Behavior and domain scores, respectively.<h4>Conclusions</h4>The EB PRO measure is a promising tool for assessing eating behaviors in people with obesity or overweight.

Item Type: Article
Uncontrolled Keywords: Humans, Obesity, Factor Analysis, Statistical, Reproducibility of Results, Feeding Behavior, Psychometrics, Adult, Aged, Middle Aged, Female, Male, Overweight, Surveys and Questionnaires, Patient Reported Outcome Measures
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Population Health
Depositing User: Symplectic Admin
Date Deposited: 02 Jun 2025 10:44
Last Modified: 14 Jul 2025 10:46
DOI: 10.1002/oby.24299
Open Access URL: https://doi.org/10.1002/oby.24299
Related Websites:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3193012
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