Barnich, Nicolas, Arthur, Janelle C, Buisson, Anthony, Campbell, Barry J 
ORCID: 0000-0002-7407-012X, Carbonnel, Franck, Chassaing, Benoit, Coombes, Brian K, Denizot, Jérémy, Dogan, Belgin, Faith, Jeremiah et al (show 10 more authors)
(2025)
Adherent-invasive Escherichia coli in Crohn’s disease: the 25th anniversary
Gut, 75 (2).
gutjnl-2025-335331-gutjnl-2025-335331.
ISSN 0017-5749, 1468-3288
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Text
Final review AIEC May 6 2025 clean version.pdf - Author Accepted Manuscript Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
In 1998, Arlette Darfeuille-Michaud, Christel Neut and Jean-Frederic Colombel discovered a novel pathovar of Escherichia coli, adherent and invasive Escherichia coli (AIEC), in the ileum of patients with Crohn's disease (CD), that was genetically distinct from diarrheagenic E. coli, could adhere to and invade intestinal epithelial cells and survive in macrophages. The consistent association between AIEC and CD (approximately 30% across the world), their ability to exploit CD-associated genetic traits, and virulence in preclinical colitis models but not healthy hosts spurred global research to elucidate their pathogenicity. Research focused on integrating AIEC with the microbiome, metabolome, metagenome, host response and the impact of diet and antimicrobials has linked the luminal microenvironment and AIEC metabolism to health and disease. This deeper understanding has led to therapeutic trials and precision medicine targeting AIEC-colonised patients. In November 2023, prominent members of the AIEC research community met to present and discuss the many facets of basic, translational and clinical AIEC fields at 'AIEC: past, present and future' in NYC. This review is a summary of this international meeting highlighting the history of AIEC, knowledge accumulated over the past 25 years about its pathogenic properties and proposes a standardised approach for screening patients for AIEC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AIEC Research group, AIEC Research Group |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 20 Jun 2025 08:52 |
| Last Modified: | 28 Feb 2026 17:23 |
| DOI: | 10.1136/gutjnl-2025-335331 |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3193334 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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