Markad, Datta, Cook, Laurence J Kershaw, Pétuya, Rémi, Yan, Yong, Gilford, Oliver, Verma, Ajay, Mali, Bhupendra P 
ORCID: 0000-0002-1699-4877, Robertson, Craig M ORCID: 0000-0002-4789-7607, Berry, Neil G ORCID: 0000-0003-1928-0738, Darling, George R ORCID: 0000-0001-9329-9993 et al (show 4 more authors)
(2024)
Recognition and order of multiple sidechains by metal–organic framework enhances the separation of hexane isomers
Angewandte Chemie, 136 (50).
ISSN 0044-8249, 1521-3757
Abstract
Abstract Porous materials perform molecular sorting, separation and transformation by interaction between their framework structures and the substrates. Proteins also interact with molecules to effect chemical transformations, but rely on the precise sequence of the amino acid building units along a common polypeptide backbone to maximise their performance. Design strategies that positionally order sidechains over a defined porous framework to diversify the internal surface chemistry would enhance control of substrate processing. Here we show that different sidechains can be ordered over a metal–organic framework through recognition of their distinct chemistries during synthesis. The sidechains are recognised because each one forces the common building unit that defines the backbone of the framework into a different conformation in order to form the extended structure. The resulting sidechain ordering affords hexane isomer separation performance superior to that of the same framework decorated only with sidechains of a single kind. The separated molecules adopt distinct arrangements within the resulting modified pore geometry, reflecting their strongly differentiated environments precisely created by the ordered sidechains. The development of frameworks that recognize and order multiple sidechain functionality by conformational control offers tailoring of the internal surfaces within families of porous materials to direct interactions at the molecular level.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 3403 Macromolecular and Materials Chemistry, 34 Chemical Sciences |
| Divisions: | Faculty of Science & Engineering Faculty of Science & Engineering > School of Physical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 29 Jul 2025 10:53 |
| Last Modified: | 23 May 2026 09:15 |
| DOI: | 10.1002/ange.202411960 |
| Open Access URL: | https://onlinelibrary.wiley.com/doi/full/10.1002/a... |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3193841 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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