Stull-Lane, Annica R, Camacho, Lizbeth, Van Hecke, Amber ER, Perez-Sepulveda, Blanca, Bejarano, Eli J, Winter, Maria G, Winter, Sebastian E, Hinton, Jay CD 
ORCID: 0000-0003-2671-6026, Baumler, Andreas J, Hiyoshi, Hirotaka et al (show 1 more authors)
(2025)
African Salmonella enterica serovar Typhimurium ST313 isolates prevent reactive oxygen species production by human neutrophils via elevated PgtE expression
MBIO, 16 (8).
pp. 1-15.
ISSN 2161-2129, 2150-7511
Abstract
A recently emerged Salmonella enterica serotype Typhimurium variant, ST313, is a frequent cause of bloodstream infections associated with high mortality rates in sub-Saharan Africa. While the interaction of ST313 strains with macrophages has been studied extensively, interactions with other innate immune effectors such as neutrophils have been largely ignored. We found that a subset of ST313 strains induces an attenuated neutrophil oxidative burst, which can facilitate increased bacterial survival within human neutrophils. The ST313 isolates that avoid triggering potent reactive oxygen species production by neutrophils express elevated levels of the protease PgtE. Increased pgtE expression promotes decreased complement deposition on S. Typhimurium and a concomitant increase in disseminated infection in mice. Our results show that high-level PgtE expression contributes to evasion of the neutrophil oxidative burst by S. Typhimurium, suggesting a possible mechanism contributing to invasive S. Typhimurium disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | <italic>Salmonella</italic>, neutrophils, complement |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 31 Jul 2025 09:12 |
| Last Modified: | 16 Jun 2026 17:11 |
| DOI: | 10.1128/mbio.01609-25 |
| Open Access URL: | https://journals.asm.org/doi/epub/10.1128/mbio.016... |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3193871 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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