Immunohistochemistry markers of molecular subtype do not correlate with the growth behaviour for recurrent meningiomas - a cohort study.

Richardson, George E, Mustafa, Mohammad A, Clynch, Abigail L ORCID: 0000-0001-8489-9137, Islim, Abdurrahman I, Mills, Samantha J, Rathi, Nitika, Zakaria, Rasheed ORCID: 0000-0001-6826-2662, Ricci, Emanuele, Ressel, Lorenzo ORCID: 0000-0002-6614-1223 and Jenkinson, Michael D ORCID: 0000-0003-4587-2139 (2025) Immunohistochemistry markers of molecular subtype do not correlate with the growth behaviour for recurrent meningiomas - a cohort study. Journal of neuro-oncology, 176 (1). p. 94. ISSN 0167-594X, 1573-7373

Text 2025_JNO_Submission_sub_Revisions.docx - Author Accepted Manuscript Available under License Creative Commons Attribution. Download (8MB)

Abstract

Introduction: Established (Ki-67, H3K27Me3) protein biomarkers correlate to clinically aggressive meningioma and can be quickly and easily assessed by immunohistochemistry (IHC). Novel (S100B, SCGN, ACADL, MCM2) markers have also been proposed. The aim of this study was to determine if IHC-based biomarker expression is correlated with volumetric growth rates in recurrent intracranial meningioma following primary resection. Methods: This was a single-centre retrospective cohort study of adults (≥ 18 years) with surgical resection of recurrent meningioma. Serial tumour volumes were calculated on serial MRI using the ellipsoid formula. Growth rates were calculated and adjusted for time since resection. IHC was performed on paired samples from first and second resections for six markers. Associations between marker expression and tumour growth trajectories were tested using Kruskal–Wallis and linear mixed-effects models. Results: Thirty-one patients were included (mean age 53.1 years, 71% female). No significant cohort differences were found in IHC expression between primary and recurrent samples (all McNemar P > 0.1). Tumours were positive for ≥ 2 novel markers in 17.2% of primary and 34.5% of recurrent samples. Neither established (Ki-67, H3K27Me3) nor novel markers predicted absolute or relative growth rates (all Kruskal–Wallis P > 0.2). Linear mixed-effects models confirmed no association between marker expression and longitudinal tumour volume trajectories (all P ≥ 0.1). Conclusion: IHC expression of established or novel markers did not correlate with meningioma volumetric growth. IHC-based stratification is limited by overlapping expression patterns and inconsistent categorisation and is not recommended for routine clinical practice.

Item Type:	Article
Uncontrolled Keywords:	Histopathology, Meningioma, Progression free survival, Reoperation, Volumetric MRI
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences > Inst. Infection, Vet & Ecological Sciences (T&R Staff) Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences > Vet Anatomy, Physiology & Pathology Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology (T&R Staff) Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Molecular & Clinical Cancer Medicine Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Pharmacology & Therapeutics
Depositing User:	Symplectic Admin
Date Deposited:	28 Nov 2025 10:26
Last Modified:	03 Dec 2025 06:23
DOI:	10.1007/s11060-025-05322-4
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3195688
Disclaimer:	The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate.