Unsworth, C 
ORCID: 0000-0002-2748-8283, Dwyer, AB, Savage, AC ORCID: 0000-0002-5312-9946, Hobson, JJ ORCID: 0000-0003-2551-1774, Massam, J, McDonald, TO ORCID: 0000-0002-9273-9173, Curley, P ORCID: 0000-0003-4596-2708, Owen, A ORCID: 0000-0002-9819-7651, O'Sullivan, A, MacLoughlin, R et al (show 1 more authors)
(2025)
Development of solid drug nanoparticle dispersions for pulmonary delivery of niclosamide and nitazoxanide via vibrating mesh nebulisation
Rsc Pharmaceutics, 2 (3).
pp. 517-526.
ISSN 2976-8713, 2976-8713
Abstract
The optimum delivery of very poorly soluble drug compounds is challenging, especially if targeting of disease sites is required. Delivery to the lung is hampered by a range of physiological issues, and inhalation may be the most appropriate route. When breathing is compromised by infection or poor lung capacity, nebulisation may enable therapeutics to be carried deep into the respiratory tract. Here we report the development of nebulised aqueous formulations of two highly water-insoluble drugs with demonstrated anti-SARS-CoV-2 activity and evaluate their pulmonary delivery using in vitro models that include the breathing patterns of children and COVID-19 infected adults.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 3206 Medical Biotechnology, 32 Biomedical and Clinical Sciences, Bioengineering, Lung, Coronaviruses, Coronaviruses Therapeutics and Interventions, Infectious Diseases, Nanotechnology, Emerging Infectious Diseases, 5.1 Pharmaceuticals, Respiratory |
| Divisions: | Faculty of Health & Life Sciences Faculty of Science & Engineering Faculty of Science & Engineering > School of Physical Sciences Faculty of Science & Engineering > School of Physical Sciences > Chemistry Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences Faculty of Health & Life Sciences > Inst. Infection, Vet & Ecological Sciences > Evolution, Ecology & Behaviour Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology (T&R Staff) Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Pharmacology & Therapeutics |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 02 Mar 2026 09:03 |
| Last Modified: | 02 Mar 2026 09:03 |
| DOI: | 10.1039/d5pm00006h |
| Open Access URL: | https://pubs.rsc.org/en/content/articlelanding/202... |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3197274 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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