Lin, Wen-Pin, Lv, Huibin, Wu, Lo-Yu, Wu, Richard, Li, Xueli and Abass, Ahmed 
ORCID: 0000-0002-8622-4632
(2026)
Design-Dependent Myopia Control in Orthokeratology: Spherical Versus Aspherical Back Optic Zone Profiles
BIOENGINEERING-BASEL, 13 (4).
414-.
ISSN 2306-5354, 2306-5354
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Text
bioengineering-13-00414.pdf - Open Access published version Download (3MB) | Preview |
Abstract
Background: This study examined spherical and aspherical orthokeratology (Ortho-K) lens designs for myopia control and corneal optical stability over the course of a year. Methods: This retrospective analysis used data from a previously conducted two-centre, single-blind, randomised contralateral-eye clinical study, in which 48 children aged 8 to 15 years wore a spherical Ortho-K lens in one eye and an aspherical lens in the other. Measurements included axial length (AL), best-corrected visual acuity (BCVA), lens decentration, corneal power, and higher-order aberrations over 12 months. Corneal topography was analysed using customised MATLAB code, Zernike fitting and paired inter-eye differences were evaluated with the Wilcoxon signed-rank test. Results: Both lenses exhibited typical Ortho-K reshaping patterns, with central flattening and mid-peripheral steepening. The aspherical lens resulted in slower AL elongation than the spherical lens (p < 0.01). It also produced smaller, more stable treatment zones and less variability in higher-order aberrations. Significant differences between the designs were found for vertical coma (p = 0.006), spherical aberration (p = 0.002), and vertical tilt (p = 0.02). Lens decentration also differed significantly (p < 0.01). Conclusions: Over 12 months, the aspherical Ortho-K lens demonstrated superior myopia control and more stable corneal optics than the spherical lens.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | eye, orthokeratology, myopia management, myopia control, aspherical geometry, decentration, axial length |
| Divisions: | Faculty of Science & Engineering Faculty of Science & Engineering > School of Engineering Faculty of Science & Engineering > School of Engineering > Materials, Design and Manufacturing Eng |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 01 Apr 2026 13:28 |
| Last Modified: | 23 May 2026 11:17 |
| DOI: | 10.3390/bioengineering13040414 |
| Open Access URL: | https://www.mdpi.com/2306-5354/13/4/414 |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3197811 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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