Enzama, Henry, Ojara, Francis Williams, Haworth, Ian S, Cvijic, Sandra, Waitt, Catriona 
ORCID: 0000-0003-0134-5855 and Grasela, Thaddeus H
(2026)
Advancing Pharmacoequity in Low- and Middle-Income Countries via Model Informed Drug Development
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 19 (5).
e70571-.
ISSN 1752-8054, 1752-8062
Abstract
Across low- and middle-income countries (LMICs) inequities in access to safe, effective medicines persist due to limited regulatory capacity, inadequate financing, and insufficient local data. Regulatory authorities are engaging with model-informed drug development (MIDD), but uneven technical readiness and resource gaps limit uptake. Physiologically based and population pharmacokinetic modeling can strengthen regulatory review and optimize dosing. When aligned with global harmonization initiatives, these tools can support evidence-based decisions and advance pharmacoequity by ensuring context-appropriate therapies reach patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Humans, Developing Countries, Economics, Pharmaceutical, Drug Development |
| Divisions: | Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences > Inst. Life Courses & Medical Sciences (T&R staff) Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences > Women's & Children's Health |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 01 May 2026 08:13 |
| Last Modified: | 04 Jul 2026 02:42 |
| DOI: | 10.1111/cts.70571 |
| Open Access URL: | https://pmc.ncbi.nlm.nih.gov/articles/PMC13112073/ |
| Related Websites: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3198258 |
| Disclaimer: | The University of Liverpool is not responsible for content contained on other websites from links within repository metadata. Please contact us if you notice anything that appears incorrect or inappropriate. |
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