Will the real K_ATP please stand up? Kir6.2/SUR2A takes the stand in the tiring case of skeletal muscle fatigue

Rainbow, Richard D ORCID: 0000-0002-0532-1992 and Barrett-Jolley, Richard ORCID: 0000-0003-0449-9972 (2026) Will the real K_ATP please stand up? Kir6.2/SUR2A takes the stand in the tiring case of skeletal muscle fatigue JOURNAL OF GENERAL PHYSIOLOGY, 158 (4). e202614036-. ISSN 0022-1295, 1540-7748

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Abstract

Scala et al. (https://doi.org/10.1085/jgp.202613986) use combined genetic and pharmacological approaches to demonstrate that Kir6.2/SUR2-containg KATP potassium ion channels are the functionally relevant isoform that modulate contractile behavior of fast-twitch muscle during fatigue.

Item Type:	Article
Uncontrolled Keywords:	Muscle, Skeletal, Animals, Humans, Muscle Fatigue, KATP Channels, Sulfonylurea Receptors
Divisions:	Faculty of Health & Life Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences > Inst. Life Courses & Medical Sciences (T&R staff) Faculty of Health & Life Sciences > Inst. Life Courses & Medical Sciences > Cardiovascular & Metabolic Medicine
Depositing User:	Symplectic Admin
Date Deposited:	03 Jun 2026 08:29
Last Modified:	01 Jul 2026 13:05
DOI:	10.1085/jgp.202614036
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3198734
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