An investigation of GRP78 expression and inhibition in squamous cell carcinoma of the head and neck


Aslam, Mohammed Afeef An investigation of GRP78 expression and inhibition in squamous cell carcinoma of the head and neck. PhD thesis, University of Liverpool.

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Abstract

GRP78 is a known cyto-protective gene which is induced in microenvironments typical of tumours with low glucose and hypoxia. Furthermore up-regulation of GRP78 has been linked to chemo- and radioresistance as well as poor survival outcome. This study is the first to confirm that GRP78 is up-regulated in tumours of the oropharynx, larynx and hypopharynx compared with matched histologically normal tissue (p(Χ2)

Item Type: Thesis (PhD)
Additional Information: alt_title: Targeting of protein chaperones as novel therapies for head and neck cancer Date: 2011-08 (completed)
Subjects: ?? RC0254 ??
Divisions: Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 23 May 2012 10:26
Last Modified: 16 Dec 2022 04:35
DOI: 10.17638/00003813
Supervisors:
  • Boyd, Mark
  • Jones, Terry
URI: https://livrepository.liverpool.ac.uk/id/eprint/3813
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