Aslam, Mohammed Afeef
An investigation of GRP78 expression and inhibition in squamous cell carcinoma of the head and neck.
PhD thesis, University of Liverpool.
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Abstract
GRP78 is a known cyto-protective gene which is induced in microenvironments typical of tumours with low glucose and hypoxia. Furthermore up-regulation of GRP78 has been linked to chemo- and radioresistance as well as poor survival outcome. This study is the first to confirm that GRP78 is up-regulated in tumours of the oropharynx, larynx and hypopharynx compared with matched histologically normal tissue (p(Χ2)
| Item Type: | Thesis (PhD) |
|---|---|
| Additional Information: | alt_title: Targeting of protein chaperones as novel therapies for head and neck cancer Date: 2011-08 (completed) |
| Subjects: | ?? RC0254 ?? |
| Divisions: | Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 23 May 2012 10:26 |
| Last Modified: | 16 Dec 2022 04:35 |
| DOI: | 10.17638/00003813 |
| Supervisors: |
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| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3813 |
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