Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes.



Wiersma, Anje C, Leegwater, Peter Aj ORCID: 0000-0002-4100-015X, van Oost, Bernard A, Ollier, William E and Dukes-McEwan, Joanna ORCID: 0000-0002-0326-8251
(2007) Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes. BMC veterinary research, 3. 28 - ?.

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Abstract

<h4>Background</h4>Dilated cardiomyopathy is a myocardial disease occurring in humans and domestic animals and is characterized by dilatation of the left ventricle, reduced systolic function and increased sphericity of the left ventricle. Dilated cardiomyopathy has been observed in several, mostly large and giant, dog breeds, such as the Dobermann and the Great Dane. A number of genes have been identified, which are associated with dilated cardiomyopathy in the human, mouse and hamster. These genes mainly encode structural proteins of the cardiac myocyte.<h4>Results</h4>We present the annotation of, and marker development for, 14 of these genes of the dog genome, i.e. alpha-cardiac actin, caveolin 1, cysteine-rich protein 3, desmin, lamin A/C, LIM-domain binding factor 3, myosin heavy polypeptide 7, phospholamban, sarcoglycan delta, titin cap, alpha-tropomyosin, troponin I, troponin T and vinculin. A total of 33 Single Nucleotide Polymorphisms were identified for these canine genes and 11 polymorphic microsatellite repeats were developed.<h4>Conclusion</h4>The presented polymorphisms provide a tool to investigate the role of the corresponding genes in canine Dilated Cardiomyopathy by linkage analysis or association studies.

Item Type: Article
Uncontrolled Keywords: Animals, Dogs, Cardiomyopathies, Dog Diseases, Genetic Markers, Microsatellite Repeats, Polymorphism, Single Nucleotide
Subjects: ?? SF ??
Divisions: Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences > School of Veterinary Science
Depositing User: Symplectic Admin
Date Deposited: 25 Jun 2008 12:47
Last Modified: 26 Apr 2022 09:15
DOI: 10.1186/1746-6148-3-28
Publisher's Statement : © 2007 Wiersma et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: https://livrepository.liverpool.ac.uk/id/eprint/677