Application and investigation of a bound for outcome reporting bias

Williamson, PR ORCID: 0000-0001-9802-6636 and Gamble, C ORCID: 0000-0002-3021-1955 (2007) Application and investigation of a bound for outcome reporting bias Trials, 8 (1). 12-. ISSN 1745-6215, 1745-6215

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Abstract

Background: Direct empirical evidence for the existence of outcome reporting bias is accumulating and this source of bias is recognised as a potential threat to the validity of meta-analysis of randomised clinical trials. Methods: A method for calculating the maximum bias in a meta-analysis due to publication bias is adapted for the setting where within-study selective non-reporting of outcomes is suspected, and compared to the alternative approach of missing data imputation. The properties of both methods are investigated in realistic small sample situations. Results: The results suggest that the adapted Copas and Jackson approach is the preferred method for reviewers to apply as an initial assessment of robustness to within-study selective non-reporting. Conclusion: The Copas and Jackson approach is a useful method for systematic reviewers to apply to assess robustness to outcome reporting bias. © 2007 Williamson and Gamble; licensee BioMed Central Ltd.

Item Type:	Article
Additional Information:	161BG Times Cited:2 Cited References Count:32## TULIP Type: Articles/Papers (Journal) ## official_url: <Go to ISI>://000245988700001
Uncontrolled Keywords:	tonic clonic seizures, comparative monotherapy trial, multicenter comparative trial, controlled clinical-trial, newly-diagnosed epilepsy, long-term retention, sodium valproate, double-blind, onset epilepsy, carbamazepine
Subjects:	?? RC0321 ??
Divisions:	Faculty of Health & Life Sciences > Inst. Systems, Molec & Integrative Biology > Inst. Systems, Molec & Integrative Biology Faculty of Health & Life Sciences
Depositing User:	Symplectic Admin
Date Deposited:	27 Jun 2008 12:59
Last Modified:	01 Mar 2026 11:51
DOI:	10.1186/1745-6215-8-9
Publisher's Statement :	© 2007 Williamson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Related Websites:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/711
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