Application and investigation of a bound for outcome reporting bias.

Williamson, Paula R ORCID: 0000-0001-9802-6636 and Gamble, Carrol ORCID: 0000-0002-3021-1955
(2007) Application and investigation of a bound for outcome reporting bias. Trials, 8 (1). 9-.

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<h4>Background</h4>Direct empirical evidence for the existence of outcome reporting bias is accumulating and this source of bias is recognised as a potential threat to the validity of meta-analysis of randomised clinical trials.<h4>Methods</h4>A method for calculating the maximum bias in a meta-analysis due to publication bias is adapted for the setting where within-study selective non-reporting of outcomes is suspected, and compared to the alternative approach of missing data imputation. The properties of both methods are investigated in realistic small sample situations.<h4>Results</h4>The results suggest that the adapted Copas and Jackson approach is the preferred method for reviewers to apply as an initial assessment of robustness to within-study selective non-reporting.<h4>Conclusion</h4>The Copas and Jackson approach is a useful method for systematic reviewers to apply to assess robustness to outcome reporting bias.

Item Type: Article
Additional Information: Published: 6 March 2007. Issue: 12 pages (page numbers not for citation purposes).
Subjects: ?? R1 ??
Divisions: Faculty of Health and Life Sciences
Depositing User: Symplectic Admin
Date Deposited: 27 Jun 2008 13:21
Last Modified: 17 Dec 2022 00:25
DOI: 10.1186/1745-6215-8-9
Publisher's Statement : © 2007 Williamson and Gamble; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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