Application and investigation of a bound for outcome reporting bias.



Williamson, Paula R ORCID: 0000-0001-9802-6636 and Gamble, Carrol ORCID: 0000-0002-3021-1955
(2007) Application and investigation of a bound for outcome reporting bias. Trials, 8. 9 - ?.

[img] PDF
721.pdf
Available under License Creative Commons Attribution.

Download (569kB)

Abstract

<h4>Background</h4>Direct empirical evidence for the existence of outcome reporting bias is accumulating and this source of bias is recognised as a potential threat to the validity of meta-analysis of randomised clinical trials.<h4>Methods</h4>A method for calculating the maximum bias in a meta-analysis due to publication bias is adapted for the setting where within-study selective non-reporting of outcomes is suspected, and compared to the alternative approach of missing data imputation. The properties of both methods are investigated in realistic small sample situations.<h4>Results</h4>The results suggest that the adapted Copas and Jackson approach is the preferred method for reviewers to apply as an initial assessment of robustness to within-study selective non-reporting.<h4>Conclusion</h4>The Copas and Jackson approach is a useful method for systematic reviewers to apply to assess robustness to outcome reporting bias.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: ?? medstat ??
Depositing User: Symplectic Admin
Date Deposited: 27 Jun 2008 13:21
Last Modified: 03 Mar 2021 09:59
DOI: 10.1186/1745-6215-8-9
Publisher's Statement : © 2007 Williamson and Gamble; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: https://livrepository.liverpool.ac.uk/id/eprint/721