The time-course of a scrapie outbreak.

McIntyre, K Marie ORCID: 0000-0003-1360-122X, Gubbins, Simon ORCID: 0000-0003-0538-4173, Goldmann, Wilfred, Stevenson, Emily and Baylis, Matthew ORCID: 0000-0003-0335-187X
(2006) The time-course of a scrapie outbreak. BMC veterinary research, 2 (1). 20-.

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<h4>Background</h4>Because the incubation period of scrapie has a strong host genetic component and a dose-response relationship, it is possible that changes will occur during an outbreak, especially in the genotypes of cases, age-at-onset of disease and, perhaps, the clinical signs displayed. We investigated these factors for a large outbreak of natural scrapie, which yielded sufficient data to detect temporal trends.<h4>Results</h4>Cases occurred mostly in two genotypes, VRQ/VRQ and VRQ/ARQ, with those early in the outbreak more likely to be of the VRQ/VRQ genotype. As the epidemic progressed, the age-at-onset of disease increased, which reflected changes in the genotypes of cases rather than changes in the age-at-onset within genotypes. Clinical signs of cases changed over the course of the outbreak. As the epidemic progressed VRQ/VRQ and VRQ/ARQ sheep were more likely to be reported with behavioural changes, while VRQ/VRQ sheep only were less likely to be reported with loss of condition.<h4>Conclusion</h4>This study of one of the largest scrapie outbreaks in the UK allowed investigation of the effect of PrP genotype on other epidemiological parameters. Our analysis indicated that, although age-at-onset and clinical signs changed over time, the observed changes were largely, but not exclusively, driven by the time course of the PrP genotypes of cases.

Item Type: Article
Additional Information: ## TULIP Type: Articles/Papers (Journal) ##
Uncontrolled Keywords: Animals, Sheep, Scrapie, Genetic Predisposition to Disease, Disease Outbreaks, Aging, Time Factors, United Kingdom
Subjects: ?? SF ??
Divisions: Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences > School of Veterinary Science
Depositing User: Symplectic Admin
Date Deposited: 01 Jul 2008 15:41
Last Modified: 17 Dec 2022 00:09
DOI: 10.1186/1746-6148-2-20
Publisher's Statement : © 2006 McIntyre et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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