Tooth dimensions in hypodontia with a known PAX9 mutation

Brook, AH, Elcock, C, Aggarwal, M, Lath, DL, Russell, JM, Patel, PI and Smith, RN
(2009) Tooth dimensions in hypodontia with a known PAX9 mutation. Archives of Oral Biology, 54 (1). S57-S62.

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Aims: Congenital absence of teeth is a complex condition affecting several parameters of oral development. This is the first study to measure tooth crown dimensions using image analysis in a family with hypodontia in whom the mutation has been identified, and compare them with a control group. Methods and Results: Study models were obtained from ten family members from three generations affected by severe hypodontia with a missense mutation in PAX9 and ten unaffected, unrelated controls. Using established image analysis techniques all teeth up to and including the first permanent molars were digitally imaged by two operators from the occlusal (O) and buccal (B) aspects three times and an average made for the mesio-distal (MDO and MDB) bucco-lingual (BL), area (A) and perimeter (P) measurements. Intra-Class Correlation Coefficients (ICCC) were calculated to assess intra- and inter-operator reliability. Two-sample t-tests were then used to compare these dimensions with those of the controls. Reliability of the technique was high (mean r>0.95). The majority of tooth types throughout the dentition were significantly smaller in the family members with hypodontia than in the control group for all parameters measured. The levels of significance were very high for upper lateral incisors (p

Item Type: Article
Additional Information: MATCHED FROM WOS Journal article ## TULIP Type: Articles/Papers (Journal) ##
Uncontrolled Keywords: Hypodontia, PAX9, Reliability, Image analysis
Subjects: ?? RK ??
Divisions: Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Dentistry
Depositing User: Symplectic Admin
Date Deposited: 19 Oct 2009 11:35
Last Modified: 16 Dec 2022 04:33
DOI: 10.1016/j.archoralbio.2008.05.017
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