Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses



Pickup, DM, Moss, RM, Qiu, D, Newport, RJ, Valappil, SP ORCID: 0000-0001-9646-8406, Knowles, JC and Smith, ME
(2009) Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses. JOURNAL OF CHEMICAL PHYSICS, 130 (6). 064708-.

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Abstract

Antimicrobial gallium-doped phosphate-based glasses of general composition (P(2)O(5))(0.45)(CaO)(0.16)(Na(2)O)(0.39-x)(Ga(2)O(3))(x) (where x=0, 0.01, 0.03, and 0.05) have been studied using the advanced synchrotron-based techniques of Ga K-edge x-ray absorption spectroscopy and high-energy x-ray diffraction to provide a structural insight into their unique properties. The results show that the Ga(3+) ions are octahedrally coordinated. Furthermore, substitution of Na(2)O by Ga(2)O(3) strengthens the phosphate network structure because the presence of GaO(6) octahedra inhibits the migration of the remaining Na(+) ions. The results are discussed in terms of the use of Na(2)O-CaO-P(2)O(5) glasses as controlled-delivery devices for antimicrobial Ga(3+) ions in biomedical applications. We are thereby able to relate the atomic-scale environment of the Ga(3+) ions beneficially to the glass dissolution, and thus to their ability to disrupt bacterial cell activity by usurping the role of iron.

Item Type: Article
Additional Information: MATCHED FROM WOS Journal article The Journal of chemical physics J Chem Phys. 2009 Feb 14;130(6):064708.## TULIP Type: Articles/Papers (Journal) ##
Uncontrolled Keywords: antibacterial activity, biomedical materials, calcium compounds, cellular biophysics, dissolving, gallium, microorganisms, phosphate glasses, sodium compounds, X-ray absorption spectra, X-ray diffraction
Subjects: ?? RK ??
Divisions: Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Dentistry
Depositing User: Symplectic Admin
Date Deposited: 27 May 2009 11:53
Last Modified: 24 Jul 2023 20:30
DOI: 10.1063/1.3076057
Publisher's Statement : Copyright 2009 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Structural characterization by x-ray methods of novel antimicrobial gallium-doped phosphate-based glasses D. M. Pickup, R. M. Moss, D. Qiu, R. J. Newport, S. P. Valappil, J. C. Knowles, and M. E. Smith, J. Chem. Phys. 130, 064708 (2009), DOI:10.1063/1.3076057 and may be found at http://link.aip.org/link/?JCPSA6/130/064708/1
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URI: https://livrepository.liverpool.ac.uk/id/eprint/1111