The effects of neoadjuvant chemoradiotherapy and a structured exercise training programme on phusical fitness and in vivo mitochrondrial function in advanced rectal cancer patients



West, Malcolm
The effects of neoadjuvant chemoradiotherapy and a structured exercise training programme on phusical fitness and in vivo mitochrondrial function in advanced rectal cancer patients. PhD thesis, University of Liverpool.

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Abstract

Outcomes after major surgery depend partly on patients’ physiological tolerance to iatrogenic trauma. Objectively measured fitness assessments (cardiopulmonary exercise testing; CPET) show a link between poor fitness and poor surgical outcome, especially in major colorectal surgery. However evidence on fitness of surgical patients undergoing neoadjuvant chemoradiotherapy (NACRT) and/or preoperative exercise training is lacking. This thesis focuses on the physiological effects of NACRT and a preoperative structured responsive exercise training programme (SRETP) on objectively measured physical fitness using cardiopulmonary exercise testing, and the related effects on mitochondrial function using 31-phosphorus magnetic resonance spectroscopy (31P MRS) in operable advanced rectal cancer patients. First, CPET variables (oxygen uptake ( o2) at estimated lactate threshold ( L) and at peak exercise) were measured in advanced rectal cancer patients pre and post-NACRT and were followed up to 1 year postoperatively. A reduction in o2 at L and o2 at Peak exercise was observed (-1.5 and -1.4 ml.kg-1.min-1 respectively; p

Item Type: Thesis (PhD)
Additional Information: Date: 2015-02-22 (completed)
Subjects: ?? RD ??
Depositing User: Symplectic Admin
Date Deposited: 05 Aug 2015 10:21
Last Modified: 17 Dec 2022 01:28
DOI: 10.17638/02007379
URI: https://livrepository.liverpool.ac.uk/id/eprint/2007379