The clinical determinants of malignant transformation in oral epithelial dysplasia

Ho, MW, Risk, JM ORCID: 0000-0002-8770-7783, Woolgar, JA, Field, EA, Field, JK ORCID: 0000-0003-3951-6365, Steele, JC, Rajlawat, BP, Triantafyllou, A, Rogers, SN, Lowe, D
et al (show 1 more authors) (2012) The clinical determinants of malignant transformation in oral epithelial dysplasia. ORAL ONCOLOGY, 48 (10). pp. 969-976.

[thumbnail of Dysplasia paper after peer review )12-3-12.docx] Text
Dysplasia paper after peer review )12-3-12.docx - Unspecified
Access to this file is embargoed until Unspecified.

Download (1MB)


<h4>Background</h4>While the size and clinical appearance are known risk factors for malignant transformation of potentially malignant oral the importance of site, grade of dysplasia and exposure to environmental carcinogens remains controversial. We aim to report the clinical determinants of malignant progression in a series of patients with histopathologically graded oral epithelial dysplasia (OED).<h4>Methods</h4>We recruited patients with a histopathological diagnosis of OED to a longitudinal observational study in a tertiary oral dysplasia clinic. Clinical, histopathological and risk factor data were recorded at baseline. One of three clinical endpoints were determined: malignant transformation, progression of dysplasia grade, remission/stable dysplasia grade.<h4>Results</h4>Ninety-one patients meeting the criteria gave consent for inclusion to the cohort, with outcomes reported after a median follow up of 48 months. An estimated 22% (SE 6%) of patients underwent malignant transformation within 5 years, with significant predictors being: non-smoking status (χ(2)=15.1, p=0.001), site (χ(2)=15.3, p=0.002), non-homogeneous appearance (χ(2)=8.2, p=0.004), size of lesion >200 mm(2) (χ(2)=4.7, p=0.03) and, of borderline significance, high grade (χ(2)=5.8, p=0.06). Gender, age, number of lesions and alcohol history did not predict for malignant transformation.<h4>Conclusions</h4>Although a number of these clinical determinants have previously been associated with higher malignant transformation in OED, the high-risk nature of lesions in non-smokers is of particular note and requires a greater emphasis and recognition amongst clinicians dealing with OED. It suggests that those non-smokers with OED, have an inherited or acquired predisposition and should be treated more aggressively; these should form the focus for further investigation.

Item Type: Article
Additional Information: ## TULIP Type: Articles/Papers (Journal) ##
Uncontrolled Keywords: Oral dysplasia, Malignant transformation, Smoking, Oral squamous cell carcinoma
Depositing User: Symplectic Admin
Date Deposited: 30 Sep 2015 08:33
Last Modified: 16 Dec 2022 12:31
DOI: 10.1016/j.oraloncology.2012.04.002
Related URLs: