Biology, genetics and imaging of glial cell tumours

Walker, C, Baborie, A, Crooks, D, Wilkins, S and Jenkinson, MD ORCID: 0000-0003-4587-2139 (2011) Biology, genetics and imaging of glial cell tumours. BRITISH JOURNAL OF RADIOLOGY, 84 (Spec I). S90-S106.

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Abstract

Despite advances in therapy, gliomas remain associated with poor prognosis. Clinical advances will be achieved through molecularly targeted biological therapies, for which knowledge of molecular genetic and gene expression characteristics in relation to histopathology and in vivo imaging are essential. Recent research supports the molecular classification of gliomas based on genetic alterations or gene expression profiles, and imaging data supports the concept that molecular subtypes of glioma may be distinguished through non-invasive anatomical, physiological and metabolic imaging techniques, suggesting differences in the baseline biology of genetic subtypes of infiltrating glioma. Furthermore, MRI signatures are now being associated with complex gene expression profiles and cellular signalling pathways through genome-wide microarray studies using samples obtained by image guidance which may be co-registered with clinical imaging. In this review we describe the pathobiology, molecular pathogenesis, stem cells and imaging characteristics of gliomas with emphasis on astrocytomas and oligodendroglial neoplasms.

Item Type:	Article
Uncontrolled Keywords:	Breast, Animals, Humans, Mice, Glioma, Astrocytoma, Oligodendroglioma, Brain Neoplasms, Magnetic Resonance Imaging, Gene Expression Profiling, Molecular Biology, Adult, Child
Depositing User:	Symplectic Admin
Date Deposited:	23 Nov 2015 09:38
Last Modified:	15 Mar 2024 03:19
DOI:	10.1259/bjr/23430927
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/2038324