RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes

McDermott, B ORCID: 0000-0002-6395-3963, Ellis, S, Bou-Gharios, G, Clegg, P ORCID: 0000-0003-0632-0032 and Tew, S ORCID: 0000-0002-1213-5418 (2016) RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes. Osteoarthritis and Cartilage, 24 (7). pp. 1263-1273.

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Abstract

This study demonstrates for the first time how RNABPs are able to affect the balance of anabolic and catabolic gene expression in human chondrocytes. The post-transcriptional mechanisms controlled by RNABPs present novel avenues of regulation and potential points of intervention for controlling the expression of SOX9 and MMP13 in chondrocytes.

Item Type:	Article
Uncontrolled Keywords:	Chondrocyte, mRNA, SOX9, MMP13
Depositing User:	Symplectic Admin
Date Deposited:	05 Apr 2016 15:41
Last Modified:	16 Dec 2022 15:24
DOI:	10.1016/j.joca.2016.01.988
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3000024