Transfer hydrogenation in aqueous media

Wei, Yawen, Wu, Xiaofeng ORCID: 0000-0001-5549-8836, Wang, Chao and Xiao, Jianliang ORCID: 0000-0003-2010-247X
(2015) Transfer hydrogenation in aqueous media. CATALYSIS TODAY, 247. pp. 104-116.

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Transfer hydrogenation has become a versatile and practical method for reduction in organic synthesis. The development of aqueous transfer hydrogenation reactions is not only fundamentally interesting in terms of understanding enzymatic catalysis, but also offers economic and environmental benefits, as water is cheap and nontoxic. In this review paper, an account of the work on transfer hydrogenation in aqueous media done by the Xiao group is given. Aqueous transfer hydrogenation of ketones, aldehydes and heterocycles as well as reductive amination reactions, including extension into biomass-derived platform molecules, has been successfully developed employing the classical Noyori-type catalysts or the newly invented iridacycles, with most of the reactions taking place "on water". Water is shown to be an enabling medium for transfer hydrogenation reactions of various features. Not only can it accelerate a reduction, it also provides a simple tool, the solution pH, to control a reaction.

Item Type: Article
Uncontrolled Keywords: Aqueous reactions, Transfer hydrogenation, Asymmetric catalysis, pH effect, Biomass
Depositing User: Symplectic Admin
Date Deposited: 08 Apr 2016 14:25
Last Modified: 19 Jan 2023 07:38
DOI: 10.1016/j.cattod.2014.03.066
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