Varying the ratio of formic acid to triethylamine impacts on asymmetric transfer hydrogenation of ketones



Zhou, Xiaowei, Wu, Xiaofeng ORCID: 0000-0001-5549-8836, Yang, Bolun and Xiao, Jianliang ORCID: 0000-0003-2010-247X
(2012) Varying the ratio of formic acid to triethylamine impacts on asymmetric transfer hydrogenation of ketones. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 357. pp. 133-140.

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Abstract

Asymmetric transfer hydrogenation (ATH) is frequently carried out in the azeotropic mixture of formic acid (F) and triethylamine (T), where the F/T molar ratio is 2.5. This study shows that the F/T ratio affects both the reduction rate and enantioselectivity, with the optimum ratio being 0.2 in the ATH of ketones with the Ru-TsDPEN catalyst. Under such conditions, a range of substrates have been reduced, affording high yields and good to excellent enantioselectivities. In comparison with the common azeotropic F-T system, the reduction is faster. This protocol improves both the classic azeotropic and the aqueous-formate system when using water-insoluble ketones. © 2012 Elsevier B.V. All rights reserved.

Item Type: Article
Additional Information: ## TULIP Type: Articles (Magazine) ##
Uncontrolled Keywords: Transfer hydrogenation, Asymmetric hydrogenation, Ketones, Ruthenium, Solvent effect
Depositing User: Symplectic Admin
Date Deposited: 11 Apr 2016 09:25
Last Modified: 16 Dec 2022 02:44
DOI: 10.1016/j.molcata.2012.02.002
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3000101