Barday, M, Ho, KYT, Halsall, CT and Aissa, C ORCID: 0000-0003-0750-9435
(2016)
Regioselective Synthesis of 3-Hydroxy-4,5-alkyl-Substituted Pyridines Using 1,3-Enynes as Alkynes Surrogates.
Organic Letters, 18 (8).
pp. 1756-1759.
Text
Organic Letters 2016, 18, 1756–1759_elements.pdf - Unspecified Download (883kB) |
Abstract
The poor regioselectivity of the [4 + 2] cycloaddition of 3-azetidinones with internal alkynes bearing two alkyl substituents via nickel-catalyzed carbon–carbon activation is addressed using 1,3-enynes as substrates. The judicious choice of substitution on the enyne enables complementary access to each regioisomer of 3-hydroxy-4,5-alkyl-substituted pyridines, which are important building blocks in medicinal chemistry endeavors.
Item Type: | Article |
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Uncontrolled Keywords: | Hydrocarbons, Pyridines, cyclization, Hydrogenation Selectivity |
Depositing User: | Symplectic Admin |
Date Deposited: | 27 Apr 2016 16:10 |
Last Modified: | 19 Jan 2023 07:37 |
DOI: | 10.1021/acs.orglett.6b00451 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3000670 |