Selection on codon usage and base composition in Drosophila americana.



de Procé, Sophie Marion, Zeng, Kai, Betancourt, Andrea J ORCID: 0000-0001-9351-1413 and Charlesworth, Brian
(2012) Selection on codon usage and base composition in Drosophila americana. Biology letters, 8 (1). pp. 82-85.

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Abstract

We have used a polymorphism dataset on introns and coding sequences of X-linked loci in Drosophila americana to estimate the strength of selection on codon usage and/or biased gene conversion (BGC), taking into account a recent population expansion detected by a maximum-likelihood method. Drosophila americana was previously thought to have a stable demographic history, so that this evidence for a recent population expansion means that previous estimates of selection need revision. There was evidence for natural selection or BGC favouring GC over AT variants in introns, which is stronger for GC-rich than GC-poor introns. By comparing introns and coding sequences, we found evidence for selection on codon usage bias, which is much stronger than the forces acting on GC versus AT basepairs in introns.

Item Type: Article
Uncontrolled Keywords: Animals, Drosophila, Codon, Likelihood Functions, Sequence Alignment, Sequence Analysis, DNA, Population Dynamics, Base Composition, Base Sequence, Molecular Sequence Data, Missouri, Male, Selection, Genetic
Depositing User: Symplectic Admin
Date Deposited: 31 Oct 2016 09:56
Last Modified: 07 Feb 2024 11:44
DOI: 10.1098/rsbl.2011.0601
Open Access URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC32599...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3004206