Low calorie sweeteners and gut microbiota



Daly, Kristian ORCID: 0000-0002-1075-1831, Darby, Alistair C ORCID: 0000-0002-3786-6209 and Shirazi-Beechey, Soraya P
(2016) Low calorie sweeteners and gut microbiota. PHYSIOLOGY & BEHAVIOR, 164 (Pt B). pp. 494-500.

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Abstract

Studies dating back to 1980s, using bacterial cultures, have reported associations between low calorie sweeteners (LCS) and alterations in bacterial composition, raising the potential that LCS might exert effects on the host via interactions with gut microbiota. However, the results of a few recent studies carried out in this area have produced controversies. There is evidence that human fecal samples, used in most human microbiome studies, may provide a poor representation of microbial contents of the proximal intestine. Furthermore, fecal short chain fatty acid levels do not exemplify the amount of short chain fatty acids produced in the intestine. Short chain fatty acids are largely absorbed in the intestine by a tightly regulated mechanism. Here we present an exemplar study showing that the determination of the molecular mechanism(s) underlying the precise mode of action of a LCS on gut microbiota allows for rational and scientifically-based recommendations.

Item Type: Article
Uncontrolled Keywords: Neohesperidin dihydrochalcone (NHDC), Intestine, Pig, Microbiota, Lactobacillus
Depositing User: Symplectic Admin
Date Deposited: 22 Feb 2017 10:26
Last Modified: 19 Jan 2023 07:26
DOI: 10.1016/j.physbeh.2016.03.014
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3004232