Electrolyte and Metabolic Disturbances in Ebola Patients during a Clinical Trial, Guinea, 2015

van Griensven, Johan, Bah, Elhadj Ibrahima, Haba, Nyankoye, Delamou, Alexandre, Camara, Bienvenu Salim, Olivier, Kadio Jean-Jacques, De Clerck, Hilde, Nordenstedt, Helena, Semple, Malcolm G ORCID: 0000-0001-9700-0418, Van Herp, Michel
et al (show 5 more authors) (2016) Electrolyte and Metabolic Disturbances in Ebola Patients during a Clinical Trial, Guinea, 2015. EMERGING INFECTIOUS DISEASES, 22 (12). pp. 2120-2127.

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By using data from a 2015 clinical trial on Ebola convalescent-phase plasma in Guinea, we assessed the prevalence of electrolyte and metabolic abnormalities at admission and their predictive value to stratify patients into risk groups. Patients underwent testing with a point-of-care device. We used logistic regression to construct a prognostic model and summarized the predictive value with the area under the receiver operating curve. Abnormalities were common among patients, particularly hypokalemia, hypocalcemia, hyponatremia, raised creatinine, high anion gap, and anemia. Besides age and PCR cycle threshold value, renal dysfunction, low calcium levels, and low hemoglobin levels were independently associated with increased risk for death. A prognostic model using all 5 factors was highly discriminatory (area under the receiver operating curve 0.95; 95% CI 0.90-0.99) and enabled the definition of risk criteria to guide targeted care. Most patients had a very low (<5%) or very high (>80%) risk for death.

Item Type: Article
Uncontrolled Keywords: Ebola-Tx Consortium, Plasma, Humans, Hemorrhagic Fever, Ebola, Electrolytes, Prognosis, Severity of Illness Index, ROC Curve, Energy Metabolism, Pregnancy, Adult, Point-of-Care Systems, Guinea, Female, Male, Clinical Trials as Topic, Young Adult, Biomarkers
Depositing User: Symplectic Admin
Date Deposited: 05 Dec 2016 07:57
Last Modified: 19 Jan 2023 07:24
DOI: 10.3201/eid2212.161136
Open Access URL: http://wwwnc.cdc.gov/eid/article/22/12/16-1136_art...
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URI: https://livrepository.liverpool.ac.uk/id/eprint/3004758