Unimolecular branched block copolymer nanoparticles in methanol for the preparation of poorly water-soluble drug nanoparticles



Liu, Jian-Hua, Wais, Ulrike, Zuo, Yan-Ming, Xiang, Yu, Wang, Yan-Hong, Jackson, Alexander W, He, Tao and Zhang, Haifei
(2017) Unimolecular branched block copolymer nanoparticles in methanol for the preparation of poorly water-soluble drug nanoparticles. JOURNAL OF MATERIALS CHEMISTRY B, 5 (3). pp. 423-427.

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Abstract

Spherical unimolecular amphiphilic branched A-B block copolymer nanoparticles in methanol are fabricated via thermal annealing using the methanolic upper critical solution temperature (UCST) of the hydrophobic block segment. These polymer nanoparticles are then used to produce an aqueous poorly water-soluble drug nanoparticle suspension with a mass : drug ratio of 1 : 1 and 100% nanoparticle yield. The drug nanoparticles in the suspension are stabilized by multiple polymer nanoparticles.

Item Type: Article
Uncontrolled Keywords: 3403 Macromolecular and Materials Chemistry, 40 Engineering, 34 Chemical Sciences, Nanotechnology, Bioengineering
Depositing User: Symplectic Admin
Date Deposited: 21 Dec 2016 11:43
Last Modified: 21 Jun 2024 06:25
DOI: 10.1039/c6tb02940j
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3004977