Identification of drug-and drug-metabolite immune responses originating from both naive and memory T cells



Gibson, Andrew, Faulkner, Lee, Wood, Sally, Park, B Kevin ORCID: 0000-0001-8384-824X and Naisbitt, Dean J
(2017) Identification of drug-and drug-metabolite immune responses originating from both naive and memory T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140 (2). 578-+.

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Abstract

Both naïve and memory T-cells from drug-naive donors can be stimulated by parent drug and drug haptens. Thus, drug-derived antigens can stimulate naïve T-cells alongside pre-existing memory T-cells through proposed heterologous immunity with an as yet undetermined peptide antigen.

Item Type: Article
Uncontrolled Keywords: T-Lymphocyte Subsets, Humans, Drug Hypersensitivity, Lymphocyte Activation, Immunologic Memory, Phenotype, Biomarkers
Depositing User: Symplectic Admin
Date Deposited: 30 Jan 2017 10:48
Last Modified: 19 Jan 2023 07:19
DOI: 10.1016/j.jaci.2016.11.032
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3005434