Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects



Marshall, CR, Marshall, CR, Howrigan, DP, Merico, D, Thiruvahindrapuram, B, Wu, W, Greer, DS, Antaki, D, Shetty, A, Holmans, PA
et al (show 257 more authors) (2017) Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. NATURE GENETICS, 49 (1). pp. 27-35.

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Abstract

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. A global enrichment of CNV burden was observed in cases (odds ratio (OR) = 1.11, P = 5.7 × 10−15), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 × 10−6). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 × 10−11) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 × 10−5). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.

Item Type: Article
Uncontrolled Keywords: Psychosis Endophenotypes International Consortium, CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium, Humans, Genetic Predisposition to Disease, Genetic Markers, Risk Factors, Case-Control Studies, Schizophrenia, Genotype, Female, Male, Genome-Wide Association Study, Genetic Loci, DNA Copy Number Variations
Depositing User: Symplectic Admin
Date Deposited: 23 Feb 2017 08:11
Last Modified: 19 Jan 2023 07:16
DOI: 10.1038/ng.3725
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3006004