Systems Approaches in Osteoarthritis: Identifying Routes to Novel Diagnostic and Therapeutic Strategies



Mueller, Alan J, Peffers, Mandy J ORCID: 0000-0001-6979-0440, Proctor, Carole J and Clegg, Peter D ORCID: 0000-0003-0632-0032
(2017) Systems Approaches in Osteoarthritis: Identifying Routes to Novel Diagnostic and Therapeutic Strategies. JOURNAL OF ORTHOPAEDIC RESEARCH, 35 (8). pp. 1573-1588.

[thumbnail of Systems review Journal_of_Orthopaedic_Research.pdf] Text
Systems review Journal_of_Orthopaedic_Research.pdf - Author Accepted Manuscript

Download (1MB)

Abstract

Systems orientated research offers the possibility of identifying novel therapeutic targets and relevant diagnostic markers for complex diseases such as osteoarthritis. This review demonstrates that the osteoarthritis research community has been slow to incorporate systems orientated approaches into research studies, although a number of key studies reveal novel insights into the regulatory mechanisms that contribute both to joint tissue homeostasis and its dysfunction. The review introduces both top-down and bottom-up approaches employed in the study of osteoarthritis. A holistic and multiscale approach, where clinical measurements may predict dysregulation and progression of joint degeneration, should be a key objective in future research. The review concludes with suggestions for further research and emerging trends not least of which is the coupled development of diagnostic tests and therapeutics as part of a concerted effort by the osteoarthritis research community to meet clinical needs. © 2017 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society. J Orthop Res 35:1573-1588, 2017.

Item Type: Article
Uncontrolled Keywords: osteoarthritis, systems biology, cartilage, modelling
Depositing User: Symplectic Admin
Date Deposited: 26 Apr 2017 09:53
Last Modified: 19 Jan 2023 07:09
DOI: 10.1002/jor.23563
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3006530