Perceptions of Research Bronchoscopy in Malawian Adults with Pulmonary Tuberculosis: A Cross-Sectional Study

McCallum, Andrew D, Nyirenda, Deborah ORCID: 0000-0002-5867-4687, Lora, Wezzie, Khoo, Saye H ORCID: 0000-0002-2769-0967, Sloan, Derek J, Mwandumba, Henry C, Desmond, Nicola ORCID: 0000-0002-2874-8569 and Davies, Geraint R ORCID: 0000-0002-3819-490X (2016) Perceptions of Research Bronchoscopy in Malawian Adults with Pulmonary Tuberculosis: A Cross-Sectional Study. PLOS ONE, 11 (10). e0165734-.

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Abstract

Bronchoscopy is an established research tool in Malawi, enabling collection of pulmonary samples for immunological, pharmacological, and microbiological studies. It is, however, an invasive clinical procedure that offers no direct benefit to volunteering participants when used in a research capacity alone, and thus informed consent is essential. This study aimed to explore TB patients' understanding of research bronchoscopy, what would motivate them to participate in research bronchoscopy, and their concerns, in order to inform consenting processes for future clinical studies. We used a qualitative research design. Two focus group discussions were conducted with community members and TB patients to understand their perceptions of bronchoscopy. Transcripts were coded by multiple co-authors and thematic content analysis was used to analyse main findings. We found that Malawian patients with pulmonary TB were willing to participate in a study using research bronchoscopy for health assessment and access to improved healthcare. We identified information of value to potential participants when consenting to that may lessen some of the anxieties expressed by participants. Patient and public involvement is essential to improve informed consent and institutional trust.

Item Type:	Article
Uncontrolled Keywords:	Humans, Tuberculosis, Pulmonary, Bronchoscopy, Focus Groups, Cross-Sectional Studies, Motivation, Biomedical Research, Adult, Income, Patient Acceptance of Health Care, Malawi
Depositing User:	Symplectic Admin
Date Deposited:	25 Apr 2017 06:14
Last Modified:	19 Jan 2023 07:06
DOI:	10.1371/journal.pone.0165734
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3006824