Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the <i>BUD13</i>/<i>ZNF259</i>/<i>APOA5</i> region and fine mapping points to rs964184 as the main driver of the association signal



Parra, Esteban J, Mazurek, Andrew, Gignoux, Christopher R, Sockell, Alexandra, Agostino, Michael, Morris, Andrew P, Petty, Lauren E, Hanis, Craig L, Cox, Nancy J, Valladares-Salgado, Adan
et al (show 2 more authors) (2017) Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the <i>BUD13</i>/<i>ZNF259</i>/<i>APOA5</i> region and fine mapping points to rs964184 as the main driver of the association signal. PLOS ONE, 12 (2). e0172880-.

Access the full-text of this item by clicking on the Open Access link.

Abstract

We carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this region using dense genome-wide data, rs964184 is the only marker included in the 99% credible set of SNPs, providing strong support for rs964184 as the causal variant within this region. The frequency of the allele associated with increased triglyceride concentrations (rs964184-G) is between 30-40% higher in Native American populations from Mexico than in European populations. The evidence currently available for this variant indicates that it may be exerting its effect through three potential mechanisms: 1) modification of enhancer activity, 2) regulation of the expression of several genes in cis and/or trans, or 3) modification of the methylation patterns of the promoter of the APOA5 gene.

Item Type: Article
Uncontrolled Keywords: Humans, Genetic Predisposition to Disease, Triglycerides, Carrier Proteins, Membrane Transport Proteins, RNA-Binding Proteins, Gene Frequency, Haplotypes, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Alleles, Adult, Middle Aged, Mexican Americans, Female, Male, Genome-Wide Association Study, Apolipoprotein A-V, White People
Depositing User: Symplectic Admin
Date Deposited: 10 Apr 2017 06:31
Last Modified: 12 Oct 2023 17:53
DOI: 10.1371/journal.pone.0172880
Open Access URL: http://journals.plos.org/plosone/article?id=10.137...
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3006901