The clinical effectiveness of insulin glargine in patients with Type I diabetes in Brazil: findings and implications

Marra, Lays P, Araujo, Vania E, Oliveira, Gerusa CC, Diniz, Leonardo M, Guerra Junior, Augusto A, Acurcio, Francisco de Assis, Godman, Brian ORCID: 0000-0001-6539-6972 and Alvares, Juliana (2017) The clinical effectiveness of insulin glargine in patients with Type I diabetes in Brazil: findings and implications. JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH, 6 (6). pp. 519-527.

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Official URL: http://dx.doi.org/10.2217/cer-2016-0099

Abstract

<h4>Aim</h4>Published studies have challenged the cost-effectiveness of insulin glargine versus neutral protamine hagedorn (NPH) insulins in Brazil with limited evidence of increased effectiveness despite considerably higher acquisition costs. However, still a controversy. Consequently, there is a need to address this.<h4>Materials & methods</h4>Retrospective cohort study of Type I diabetes patients receiving insulin glargine in Brazil following NPH insulin who met the criteria.<h4>Results</h4>580 patients were enrolled. HbA<sub>1c</sub> varied from 8.80 ± 1.98% in NPH insulin users to 8.54 ± 1.88% after insulin glargine for 6 months, which is not clinically significant. Frequency of glycemic control varied from 22.6% with NPH insulin to 26.2% with insulin glargine. No statistically significant difference was observed between controlled and still uncontrolled groups for all analyzed factors including type and frequency of insulin use and carbohydrate counting.<h4>Conclusion</h4>Limited differences between NPH insulins and insulin analogs in routine clinical care do not justify an appreciable cost difference.

Item Type:	Article
Uncontrolled Keywords:	Brazil, comparative effectiveness research, insulin glargine, longitudinal studies, NPH insulin, Type I diabetes
Depositing User:	Symplectic Admin
Date Deposited:	13 Jun 2017 07:08
Last Modified:	20 Feb 2023 10:41
DOI:	10.2217/cer-2016-0099
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3007951