Management of proliferative verrucous leukoplakia: Justification for a conservative approach.


Borgna, SC, Clarke, PT, Schache, AG ORCID: 0000-0001-9466-6038, Lowe, D, Ho, MW, McCarthy, CE, Adair, S, Field, EA, Field, JK ORCID: 0000-0003-3951-6365, Holt, D et al (show 4 more authors) (2017) Management of proliferative verrucous leukoplakia: Justification for a conservative approach. Head & neck, 39 (10). pp. 1997-2003.

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Abstract

Background Proliferative verrucous leukoplakia (PVL) is a progressive, multifocal, exophytic form of leukoplakia with high rates of malignant transformation. The purpose of this study was to evaluate a cohort of patients with PVL in a single tertiary referral clinic. Method Cases meeting accepted diagnostic criteria were reviewed with regard to their pathology, demographic characteristics, management, and outcomes. Human papillomavirus (HPV) testing was undertaken on a subset. Results Almost half of the 48 patients with PVL (48%; n = 23) underwent malignant transformation after a median 23.4 months. The characteristics of this cohort were similar to those previously described, but management was notably more conservative. Conservative management of PVL was used in 92% of our patients, but the clinical outcomes seem comparable with previously described cohorts in which PVL was predominantly treated by surgical excision. All HPV testing was negative. Conclusion Aggressive surgical intervention in the premalignant phase of PVL may not influence the rate of malignant transformation.

Item Type: Article
Uncontrolled Keywords: malignant, management, proliferative verrucous leukoplakia
Depositing User: Symplectic Admin
Date Deposited: 12 Sep 2017 06:19
Last Modified: 19 Jan 2023 06:54
DOI: 10.1002/hed.24845
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3009418
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